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Home > Our scientific expertise > Veterinary products > Reference reagents
OIE-approved International Standard Sera
The OIE Biological Standards Commission (Laboratories Commission) coordinates a programme for the preparation, validation and distribution of OIE-approved International Reference Standards for antibody assays for infectious diseases of animals. The standards are prepared by an OIE Reference Laboratory in accordance with Guidelines drawn-up by the Laboratories Commission and in collaboration with other laboratories. Such standard preparations are designated by the OIE as primary reference standards for use in conjunction with tests described in the OIE Manual of Diagnostic Tests and Vaccines for Terrestrial Aniamls (mammals, birds and bees). The aim of the programme is to harmonise diagnostic testing and encourage the mutual recognition of test results for international trade.
Currently available OIE-approved International Standard Sera
Disease | Test | Available from |
African horse sickness | Enzyme-linked immunosorbent assay | Marisa Arias |
Aujeszky's disease | Enzyme-linked immunosorbent assay; | Dr André Jestin |
Contagious bovine pleuropneumonia | Both irradiated and non-irradiated sera are available. Please contact the Reference Laboratory (Dr Pini) for advice on their suitability for different types of serological test (complement fixation test, indirect or competitive enzyme-linked immunosorbent assay) | Dr Attilio Pini |
Equine infectious anaemia | Agar gel immunodiffusion | Dr Stephan Zientara |
Bluetongue | Enzyme-linked immunosorbent assay; | Dr Eileen N. Ostlund |
Bovine brucellosis | Indirect and Competitive enzyme-linked immunosorbent assay; Complement fixation; Agglutination; Buffered Brucella antigen tests; Fluorescence polarisation assay | Dr Judith A. Stack |
Brucella abortus | Complement fixation; Agglutination; Buffered Brucella antigen tests; Fluorescence polarisation assay; Indirect and Competitive enzyme-linked immunosorbent assay | Dr Judith A. Stack |
Ovine and caprine brucellosis (anti-Brucella melitensis | Indirect and Competitive enzyme-linked immunosorbent assay; Fluorescence polarisation assay; Buffered Brucella antigen tests | Dr Judith A. Stack |
Brucella ovis | Complement fixation | Dr Judith A. Stack |
Classical swine fever | Virus neutralisation | Dr Trevor Drew |
Enzootic bovine leukosis | Agar gel immunodiffusion | Prof. Thomas Vahlenkamp |
Enzootic bovine leukosis | Enzyme-linked immunosorbent assay | Dr Bhudipa Choudhury |
Equine influenza | Haemagglutination inhibition; single radial haemolysis | Dr Marie-Emmanuelle Behr-Gross |
Equine influenza | Antigens and antisera for | NIBSC (National Institute for Biological Standards and Control), P.O. Box 1193, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QH, United Kingdom |
Equine viral arteritis | Virus neutralisation | Dr Peter J. Timoney |
Foot and mouth disease | Enzyme-linked immunosorbent assay (antigen and antibody detection); | Dr Jef Hammond |
Foot and mouth disease | Nonstructural protein tests | Dr Rossana Allende |
Infectious bovine rhinotracheitis | Virus neutralisation; | Dr Eric Dubois Dr J.A. Kramps |
Peste des petits ruminants | Enzyme-linked immunosorbent assay | Dr Genevieve Libeau |
Rabies | Fluorescent antibody virus neutralisation | Dr Florence Cliquet |
Rinderpest | Enzyme-linked immunosorbent assay | Dr Michael Baron |
Swine vesicular disease | Enzyme-linked immunosorbent assay (antibody detection); Virus neutralisation | Dr Jef Hammond |
The term 'International Standard Serum' is synonymous with primary standard. It represents the standard serum by which all others (secondary standards) are compared and calibrated. Secondary standards may represent national standards or working standards that are in routine use at the diagnostic laboratory level. The secondary standard and not the International Standard are to be used on a daily basis to standardise testing. The International Standard Sera listed above may be obtained, in small quantities, at the corresponding address. Some laboratories may make a charge for this service.
Contact : scientific.dept@oie.int