MERS-CoV,
Qatar
Information received on 22/04/2014 from Dr Kassem Nasser Al-Qahtani, Director of Dept of Animal resources, Ministry of Environment, Department of Animal resources, DOHA, Qatar
Summary
Report type Follow-up report No. 2
Date of start of the event 14/10/2013
Date of confirmation of the event 26/11/2013
Report date 22/04/2014
Date submitted to OIE 22/04/2014
Reason for notification Emerging disease
Morbidity 3.8 %
Mortality 0 %
Zoonotic impact Asymptomatic exposure of camel to MERS-CoV (laboratory advanced) and one outbreak in a specific zone (Shahanya)
Causal agent MERS-CoV
Related reports Immediate notification (28/11/2013)
Follow-up report No. 1 (29/12/2013)
Follow-up report No. 2 (22/04/2014)
Follow-up report No. 3 (09/06/2014)
New outbreaks (1)
Outbreak 1 Al-Shahanya, Al-Shahanya, Ar Rayyan, Ar Rayyan
Date of start of the outbreak 11/02/2014
Outbreak status Continuing (or date resolved not provided)
Epidemiological unit Farm
Affected animals
Species Susceptible Cases Deaths Killed and disposed of Slaughtered
Camelidae 26 1 0 0 0
Affected population A single barn of 26 camels of different ages.
Summary of outbreaks Total outbreaks: 1
Total animals affected
Species Susceptible Cases Deaths Killed and disposed of Slaughtered
Camelidae 26 1 0 0 0
Outbreak statistics
Species Apparent morbidity rate Apparent mortality rate Apparent case fatality rate Proportion susceptible animals lost*
Camelidae 3.85% 0.00% 0.00% 0.00%
*Removed from the susceptible population through death, destruction and/or slaughter
Epidemiology
Source of the outbreak(s) or origin of infection
  • Unknown or inconclusive
Epidemiological comments During an existing survey (pilot phase of the survey), nasal swabs were collected from an 8-month-old camel among healthy dromedary camels. The sample was inoculated on Vero cells and cytopathic changes were observed in cells at 48h post-infection. Human hepatoma cells (Huh-7 cells) were inoculated with MERS-CoV to further functionally characterize this viral isolate. After two days, virus-induced cytopathic effects were observed in the inoculated cell cultures. Virus production in Huh-7 cells was blocked by pre-incubating MERS-CoV with a 1/200 dilution of serum from MERS-CoV antibody positive camels. Conclusion: these data demonstrate that the MERS-CoV obtained from a dromedary camel is able to replicate in human cells and uses DPP4 as entry receptor, similar as isolates obtained from MERS patients.
Control measures
Measures applied
  • Vaccination permitted (if a vaccine exists)
  • No treatment of affected animals
Measures to be applied
  • Movement control inside the country
  • Screening
  • Quarantine
Diagnostic test results
Laboratory name and type Species Test Test date Result
Department of Viroscience, Erasmus Medical Center, Rotterdam (The Netherlands) (Foreign laboratory) Camelidae real-time PCR 19/04/2014 Positive
Department of Viroscience, Erasmus Medical Center, Rotterdam (The Netherlands) (Foreign laboratory) Camelidae virus isolation 19/04/2014 Positive
Future Reporting
The event is continuing. Weekly follow-up reports will be submitted.
Map of outbreak locations