West Nile fever
West Nile fever is a disease caused by West Nile Virus (WNV), which is a flavivirus related to the viruses that cause St. Louis encephalitis, Japanese encephalitis, and yellow fever. It causes disease in humans, horses, and several species of birds. Most infected individuals show few signs of illness, but some develop severe neurological illness which can be fatal. West Nile Virus has an extremely broad host range. It replicates in birds, reptiles, amphibians, mammals, mosquitoes and ticks. West Nile Fever is a disease listed in the OIE Terrestrial Animal Health Code and must be reported by Members according to the OIE Code
West Nile fever is a disease caused by West Nile Virus (WNV), which is a flavivirus related to the viruses that cause St. Louis encephalitis, Japanese encephalitis, and yellow fever. It causes disease in humans, horses, and several species of birds. Most infected individuals show few signs of illness, but some develop severe neurological illness which can be fatal. West Nile Virus has an extremely broad host range. It replicates in birds, reptiles, amphibians, mammals, mosquitoes and ticks.
West Nile Fever is a disease listed in the World Organisation for Animal Health (OIE) Terrestrial Animal Health Code and must be reported to the OIE.
The reservoir of the virus is in birds. Mosquitoes become infected when they bite an infected bird ingesting the virus in the blood. The mosquitoes act as carriers (vectors) spreading the virus from an infected bird to other birds and to other animals. Thus, there is a cycle of the virus circulating from bird to bird by way of mosquito bites, being amplified at each cycle. Some bird species are more susceptible to the virus than others, especially the crow family (corvidae). Finding dead crows can therefore signal the presence of West Nile disease so surveillance programs often target dead crows.
Infection of other animals (e.g. horses, and also humans) is incidental to the cycle in birds since most mammals do not develop enough virus in the bloodstream to spread the disease.
West Nile fever is a zoonosis (an animal disease affecting humans). People are susceptible to the disease, however most have no symptoms. About twenty percent have mild flu-like symptoms of fever, headaches and rashes. In rare cases it can cause encephalitis. However, less than one percent of infected persons will go on to develop severe symptoms. In 2007 in the United States 121 persons died due to West Nile fever.
West Nile fever is primarily a disease of humans, equines and some birds.
In horses, clinical signs of the neurologic disease caused by West Nile Virus may include loss of appetite, depression, stumbling, muscle twitching, partial paralysis, impaired vision, head pressing, teeth grinding, aimless wandering, convulsions, circling, and an inability to swallow. Weakness, usually in the hind limbs, is sometimes followed by paralysis. Coma and death may occur. Fever has been seen in some but not all cases.
Many species of birds are resistant to the disease. Susceptible birds such as geese show various degrees of neurologic involvement ranging from lying down to leg and wing paralysis. They are either reluctant or unable to move when disturbed, and may be uncoordinated. Mortality rates of 20-60% have been reported in geese.
There are no specific treatments for the disease other than supportive care for the patient. Most animals or people affected recover spontaneously.
Clinical symptoms as described above may hint at the presence of West Nile fever. The diagnosis is confirmed by finding the antibodies in the blood of infected animals or persons. OIE recommendations can be found in the OIE .
West Nile fever is a disease listed by the OIE requiring member countries to report its occurrence.
Key to preventing the spread of West Nile fever is to control mosquito populations. Horses should be protected from exposure to mosquitoes. Likewise, people should avoid exposure to mosquitoes especially at dusk and dawn when they are most active, use insect screens and insect repellents, and limit places for mosquitoes to breed.
There is a vaccine for horses. In areas where the disease is common, vaccination of horses is considered to be an effective control measure. The international standards for the use of West Nile vaccine can be found in the OIE .
Surveillance programmes in wild or sentinel birds allow the competent authorities to take appropriate measures to protect animals and people. As birds in the crow family are very susceptible, these programmes often encourage people to report dead crows for testing.
First isolated in Uganda in 1937, West Nile Virus was described as the cause of a West Nile fever epidemic in humans in Israel in 1951. The role of mosquitoes in viral transmission was clearly delineated in Egypt in the 1950s. Wild birds were identified as the reservoir of the virus around the same time. Cases of West Nile fever in horses were reported several years later. The virus was first associated with disease in domestic avian species in 1997, when flocks of young geese in Israel were affected with a disease causing paralysis.
In August 1999, the disease appeared for the first time in the Western Hemisphere, most likely through the importation of an infected bird, causing deaths in wild and zoo birds, horses, and humans in the New York City area. In less than 10 years it spread across all of North America including Mexico and Canada, and entered South America. Since 1998, outbreaks of equine West Nile encephalitis have been reported from Italy, France, and North America. Surveys in parts of Europe and the Middle East have shown that up to a third of horses tested have been exposed to the virus even in the absence of clinical disease.