- Antimicrobial agents are medicines used to treat infections, particularly those of bacterial origin. These medicines are essential to protect human and animal health, as well as animal welfare. Excessive or inappropriate use can lead to the emergence of resistant bacteria which do not respond to antibiotic treatment, as seen in recent decades. This phenomenon, called antimicrobial resistance, which poses a threat to disease control throughout the world, is a primary concern for human and animal health, and it is the focus of the OIE AMR Working Group.
It is by ensuring the responsible and prudent use of these invaluable medicines in animals, in accordance with the intergovernmental standards of the OIE that we will be able to safeguard their efficacy.
To achieve this, coordinated action between the human and animal health and environmental sectors is crucial.
Veterinarians are part of the solution; but they must be well trained and well supervised by the statutory veterinary bodies created by law.
Antimicrobial agents are a global public good.
We each have a role to play in the fight against antimicrobial resistance and, in so doing, can protect the efficacy of these vital treatments and, by the same token, our future.
World Antimicrobial Awareness Week
Scientific and Technical Review
- Antimicrobial resistance in animal and public health, Vol. 31(1), 2012
While the massive use of antimicrobials has taken place in human and animal health over recent decades, the world is confronting an accelerated increase in the emergence of antimicrobial resistance. Yet the discovery of new treatments is not enough to maintain the fight against bacteria, organisms responsible for often serious illnesses in people and animals.
Furthermore, globalisation of the trade in food products, together with traditional and medical tourism, is allowing existing or future resistant bacteria to colonise the entire planet with ease, whatever local preventive measures are applied. Risks taken by one country are thus liable to endanger the effectiveness and availability of antibiotics for the whole planet.
Protecting the efficacy of antimicrobial agents
Antimicrobial resistance poses a worldwide health threat: its consequences, direct and indirect, can damage both human and animal health.
For those in the animal health sector, the use of veterinary medicinal products, including antimicrobial agents, is essential for the following reasons
- To protect animal health and welfare, in the knowledge that animal diseases can cause production losses of up to 20%
- To contribute to food safety, as world population growth leads to an increase in the demand for high-quality animal protein, for example, that found in eggs, meat and milk;
- To protect public health, because more than 60% of infectious animal diseases are transmissible to humans.
For all these reasons, antimicrobial agents constitute a global public good, and protecting their efficacy remains crucial.
Rationalising and supervising the use of antimicrobial agents
The OIE recommends policies enabling a basic veterinary network for effective animal health surveillance that ensures the early detection of potential animal diseases (including zoonoses) and rapid response to contain them at the site of the outbreak. This network also guarantees a general level of animal health, facilitating the sensible, appropriate and limited use of veterinary products and antibiotics.
The OIE advocates the responsible and prudent use of antimicrobial agents, under the supervision of veterinarians who have been well trained and well supervised by veterinary statutory bodies. In this context, the Organisation publishes intergovernmental standards, guidelines and recommendations aimed at the Veterinary Services of its Member Countries.
Surveillance of the use of antimicrobial agents in animals
In many countries, including developed countries, antimicrobial agents are widely available to all, directly and indirectly, with hardly any restrictions on appropriate conditions for the importation, production, distribution and use of veterinary products, including antimicrobial agents. Thus, these products are circulating like ordinary goods, without controls, and are often adulterated.
Moreover, as yet there is no harmonised surveillance system to monitor the use and circulation of antimicrobial agents in animals worldwide. Collecting this information would enable countries to better control the quality and effectiveness of the products being used. It is in this context that the OIE has been mandated by its Member Countries to collect this missing information and establish a worldwide database to monitor the use of antimicrobial agents in animals. This database, which will eventually be linked to the OIE World Animal Health Information System (OIE-WAHIS), will make it easier to analyse and control the source of imported medicines, improving their traceability by OIE Member Countries.
Developing alternative treatments to antibiotics
The OIE supports new research into alternatives to antibiotics (notably vaccines) and particularly welcomed an international symposium on the subject in 2012, organised by the International Alliance for Biological Standardization (IABS) and the United States Department of Agriculture (USDA).
Antimicrobial resistance is a global human and animal health concern which is influenced by the use of antimicrobial agents in both human and veterinary medicine, as well as in the plant sector. The human, animal and plant health sectors therefore have a shared responsibility to prevent or minimise antimicrobial resistance selection pressures on both human and non-human pathogens.
The OIE has worked actively for more than ten years on the issue of veterinary products (including antimicrobial agents) and developed a coherent strategy for its activities in this area. Sine antimicrobial resistance is an animal and human health issue, the OIE works closely with its Member Countries, WHO, FAO and the Codex Alimentarius Commission.
Following the FAO/OIE/WHO workshops on non-human antimicrobial use and antimicrobial resistance held in 2003 (on scientific assessment) and in 2004 (on management options), the OIE developed a list of antimicrobial agents of veterinary importance, in parallel with the WHO list for human medicine.
In 2016, the OIE’s 84th General Assembly unanimously adopted Resolution no. 36 , which mandates that OIE compile AMR activities into a strategy. On November 2016 the OIE Strategy on Antimicrobial Resistance and the Prudent Use of Antimicrobials was published. Aligned with the WHO Global Action Plan the strategy recognizes the importance of a “One Health” approach involving human and animal health, agricultural and environmental needs. It outlines the goals and tactics the OIE has in place to support Member Countries in their fight against AMR, and to encourage the national ownership and implementation of international Standards.
Fact Sheet, Strategic Plan.pdf – 356 KB See the document
Infographic, Strategic Plan
OIE intergovernmental standards
The OIE promotes the responsible and prudent use of antimicrobial agents in terrestrial animals, so as to preserve their therapeutic efficacy and prolong their use in both animals and humans. It has developed intergovernmental standards on antimicrobial resistance and on the monitoring of the quantities of antimicrobial agents used.
The OIE has also developed standards and guidelines to provide methodologies for OIE Member Countries to appropriately address the risk of the emergence or spread of resistant bacteria that result from the use of antimicrobial agents in food-producing animals.
Its texts cover both terrestrial animals and aquatics animals and are found in the following publications:
• Terrestrial Animal Health Code (chapters 6.7., 6.8., 6.9., 6.10. and 6.11.
•Manual of Diagnostic Tests and Vaccines for Terrestrial Animales (Chapter 2.1.1.)
• Aquatic Animals Health Code (Chapters 6.1., 6.2., 6.3. , 6.4. and 6.5.)
These standards are regularly updated to take account of the latest scientific findings (latest update in May 2015).
Global database on antimicrobial agents intended for use in animals
In the framework of the Global Action Plan on Antimicrobial Resistance (AMR), the OIE, supported by FAO and WHO within the tripartite collaboration, has taken the lead to build a global database on antimicrobial agents intended for use in animals. The OIE’s partners acknowledge this accomplishment as a major milestone in the global effort to contain antimicrobial resistance. The database is designed to:
• Monitor the type and use of antimicrobial products
• Measure trends over time
• Trace circulation and use patterns globally
• Evaluate the quality and authenticity of antimicrobial products in use
The OIE Database on antimicrobial agents intended for use in animals in OIE Member Countries was launched in October 2015.
The template for data submission and relevant guidance documents were developed by the OIE ad hoc Group on Antimicrobial Resistance, endorsed by the Scientific Commission for Animal Diseases and tested by Member Countries. Each successive year of data collection provides valuable feedback from Member Countries towards improvement of the template through this same process.
The template is designed to allow all countries to complete it, irrespective of whether national data collection system exists.
OIE Annual Report on Antimicrobial Agents Intended for Use in Animals
The OIE publishes an annual report on the use of antimicrobial agents intended for use in animals following the annual round of data collection sent to its Members, that takes place between September and May.
The latest report, published in April 2021, provides specific information on the global use of antimicrobial agents adjusted for animal biomass for the year 2017, and presents the overall findings of the fifth annual data collection on the use of antimicrobial agents in animals.
The fifth round of data collection took place between September 2019 and May 2020. Contributions to the OIE Database have grown from reporting data from 130 Members for its first report in 2016 to 160 countries for its fifth report: 156 OIE Members (86% of 182 OIE Members), one non-contiguous territory of an OIE Member and three non-OIE Members.
The fifth round includes evidence on the barriers that 23 countries experienced in reporting quantitative data on antimicrobial agents intended for use in animals.
This report provides calculations of animal biomass for food-producing species from 102 countries reporting quantitative data for the year 2017 and allowed for an analysis of antimicrobial quantities reported adjusted by a denominator.
Additionally, and for the first time, the OIE is presenting trends of the mg/kg, quantities by antimicrobial classes and animal biomass from 2015 to 2017 for 69 countries.
Previous OIE Reports
- Fourth OIE Annual Report (published 2020)
- Third OIE Annual Report (published 2019)
- Second Annual Report (published 2017)
- First Annual Report (published 2016)
OIE Template, Guidance and Calculations
The OIE considered the experience and feedback from Member Countries and annually update the template and guidance document based on requests for clarification from responding Members. The current version of these documents, are available below.
Network of OIE Experts on Antimicrobial Resistance
Resolution adopted by the World Assembly of Delegates
83rd General Session, May 2015
Resolution No. 26: Combating antimicrobial resistance and promoting the prudent use of antimicrobial agents in animals
84th General Session, May 2016
Resolution No. 36: Combating Antimicrobial Resistance through a One Health Approach: Actions and OIE Strategy
85th General Session, May 2017
Resolution No. 38: Global action to alleviate the threat of antimicrobial resistance: progress and opportunities for future activities under the ‘One health’ initiative
86th General Session, May 2018
Resolution No. 21: List of antimicrobial agents of veterinary importance
87th General Session, May 2019
Resolution No. 14: OIE’s Engagement in the One Health Global Effort to Control Antimicrobial Resistance
OIE Global Conference
THE RESPONSIBLE AND PRUDENT USE OF ANTIMICROBIAL AGENTS FOR ANIMALS
“International Solidarity in the Fight Against Antimicrobial Resistance”
(OIE Headquarters, Paris, 13-15 March 2013)
2nd OIE Global Conference
ANTIMICROBIAL RESISTANCE AND PRUDENT USE OF ANTIMICROBIAL AGENTS
Putting Standards into Practice
Marrakesh (Morocco), 29-31 October 2018
OIE Manual of diagnostic tests and vaccines for Terrestrial Animals
- Chapter 2.1.1. Laboratory methodologies for bacterial antimicrobial susceptibility testing
The OIE promotes the responsible and prudent use of antimicrobial agents in terrestrial and aquatic animals, so as to preserve their therapeutic efficacy and prolong their use in both animals and humans.
It has developed a wide range of international standards and guidelines in this field. These provide a framework for responsible and prudent use of antimicrobial products in animals and for the surveillance and monitoring of the quantities used:
Introduction to the recommendations for controlling antimicrobial resistance
|Chapter 6.1.Introduction to the recommendations for controlling antimicrobial resistance|
|Chapter 6.8.Harmonisation of national antimicrobial resistance surveillance and monitoring programmes||Chapter 6.2.Principles for responsible and prudent use of antimicrobial agents in aquatic animals|
|Chapter 6.9.Monitoring of the quantities and usage patterns of antimicrobials agents used in food producing animals||Chapter 6.3.Monitoring of the quantities and usage patterns of antimicrobial agents used in aquatic animals|
|Chapter 6.10.Responsible and prudent use of antimicrobial agents in veterinary medicine||Chapter 6.4.Development and harmonisation of national antimicrobial resistance surveillance and monitoring programmes for aquatic animals|
|Chapter 6.11.Risk analysis for antimicrobial resistance arising from the use of antimicrobials in animals||Chapter 6.5.Risk analysis for antimicrobial resistance arising from the use of antimicrobial agents in aquatic animals|
Furthermore, the OIE developed a list of antimicrobial agents of veterinary importance, in parallel with the existing WHO list for human medicine.
OIE LIST OF ANTIMICROBIAL AGENTS OF VETERINARY IMPORTANCE
The OIE has also developed standards and guidelines to provide methodologies to appropriately address the risk of the emergence or spread of resistant bacteria that result from the use of antimicrobial agents in food-producing animals:
MANUAL OF DIAGNOSTIC TESTS AND VACCINES FOR TERRESTRIAL ANIMALS
Laboratory methodologies for bacterial antimicrobial susceptibility testing
These Standards have been adopted by OIE’s 182 Member Countries and are regularly reviewed and updated, in line with the latest scientific findings.
All OIE Standards and Guidelines on the topic are also gathered in the following book:
Limiting the emergence of antimicrobial resistance requires a global, harmonised and intersectoral approach that enables the coordination of medical, animal health and environmental policies. Indeed, people and animals share the same bacteria, since 60% of infectious animal diseases are transmissible to humans. This is the foundation of the ‘One Health’ concept.
It is in this context that the OIE cooperates with many other international organisations, such as WHO, FAO, Codex alimentarius, the WTO and, more recently, INTERPOL, all of whom are key partners in sharing information, developing recommendations and preventing the traffic in counterfeit products.
Since 2010, the OIE has committed itself to a Tripartite Alliance with WHO and FAO. In 2017, their second strategic document was released and a Memorandum of Understanding (MOU) was formally signed in June 2018 by the organisations to reaffirm their commitment, establishing respective responsibilities for these three organisations in combating diseases that have major health and economic impacts, particularly zoonoses. Antimicrobial resistance is one of the Tripartite’s three priority issues.
The Tripartite alliance agrees to collaborate on:
- Supporting the continued implementation of the Global Action Plan on AMR;
- Engaging with countries to reinforce national and regional human health, animal health and food safety services;
- Improving inter-agency collaboration in foresight analysis, risk assessment, preparedness building and joint responses to emerging, reemerging and neglected infectious diseases at the animal-human-ecosystems interface;
- Addressing food safety challenges requiring a multi-sector approach in the context of reinforcing food security;
- Promoting coordinated research and development to achieve a common understanding of the highest priority zoonotic diseases and the research and development needed to prevent, detect, and control them; and
- Developing a Voluntary Code of Conduct to reinforce the implementation of international standards on responsible and prudent use of antimicrobials.
Global Action Plan on Antimicrobial Resistance
The OIE recently played a significant role in developing the WHO Global Action Plan on Antimicrobial Resistance(GAP), adopted in 2015 and aimed at ensuring our long-term capability to treat infectious diseases with effective and high-quality antimicrobials. The Member Countries of the OIE pledged their support to this plan of action through a Resolution, unanimously adopted in May 2015.
Within the framework of key activities which should be implemented over the next five to ten years, this GAP highlights the importance of the OIE intergovernmental standards and supports the establishment of a worldwide database on the use of antimicrobial agents in animals by the OIE.
Monitoring and Evaluation of the Global Action Plan on AMR
To collaboratively monitor and evaluate the global GAP indicators to inform on strategic decision-making the tripartite developed the dynamic Monitoring and Evaluation (M&E) Framework to assess the progress of country governments, the Tripartite organisations and other national and international partners in fulfilling their roles and responsibilities to impact change to combat the threat of antimicrobial resistance.
The United Nations Secretary General Report
The September 2016 Political Declaration of the High-level Meeting on Antimicrobial Resistance (Resolution A/RES/71/3) called for the establishment of the ad-hoc Interagency Coordination Group on Antimicrobial Resistance (IACG), in consultation with the Tripartite (FAO, OIE, WHO). The IACG’s mandate was to provide practical guidance for approaches needed to ensure sustained effective global action to address antimicrobial resistance, and to report back to the UN Secretary-General.
On 29 April 2019, the IACG Secretariat handed off the Recommendations Report to the Secretary-General of the UN. A united effort for the Tripartite, the report contains critical recommendations to combat drug-resistant infections and demanding immediate, coordinated and ambitious action to avert a potentially disastrous drug-resistance crisis. Furthermore, the OIE World Assembly of Delegates strengthened its commitment to the Tripartite at the 87th General Session by passing Resolution No. 14 to a Joint Tripartite Secretariat and AMR Multi-Partner Trust Fund for rapid implementation of recommendations.
Surveillance of bacterial resistance and the use of antimicrobial agents in animals
In many countries today, including developed countries, antimicrobial agents are widely available, directly or indirectly, with virtually no restrictions. Of the 135 countries recently assessed by the OIE, many have not yet passed relevant legislation to ensure appropriate conditions for the importation, manufacturing, distribution and use of veterinary products, including antimicrobial agents. As a result, these products circulate freely, like ordinary goods, and are often adulterated.
Moreover, as there is no harmonised surveillance system for the use and circulation of antimicrobial agents in animals worldwide. Collecting such information would enable countries to better control the quality and effectiveness of the products in use. It is in this context that the OIE has been mandated by its Member Countries to collect the missing information and establish a worldwide database to monitor the use of antimicrobial agents in animals. This database, which will eventually be linked to the Worldwide Animal Health Information System OIE-WAHIS, will make it easier to analyse and control the source of imported medicines, improving their traceability by OIE Member Countries.
Taking action against antimicrobial resistance, key component of the action plan for the Global Health Security Agenda (GHSA)
The OIE participates in the world Steering Committee of the GHSA, launched in 2014, as an advisor. The GHSA programme is a joint endeavour between the United States of America and more than 40 other nations, in addition to international organisations, such as WHO, the OIE and FAO. With tackling antimicrobial resistance among its primary objectives, this programme aims to accelerate progress towards a world that is better protected from infectious disease threats and to promote world health security as an international priority.
 World Health Organization
 Food and Agriculture Organization of the United Nations
 World Customs Organization
- Global Action Plan on AMR (2015)
- IACG Recommendations Report (2019)
- AMR Global Action Plan M&E (2019)
- Technical brief on water, sanitation, hygiene and wastewater management to prevent infections and reduce the spread of antimicrobial resistance (2020)
- International instruments on the use of antimicrobials across the human, animal and plant sectors (2020)
- Global Leaders Group on Antimicrobial Resistance (GLG)
- Strategic framework for collaboration on antimicrobial resistance – together for One Health (2022)
Success against antimicrobial resistance can only be achieved when the public, veterinary and environmental health authorities put these global strategies into place at the national level.
For national animal health services, implementing the OIE’s intergovernmental standards involves:
- the presence of adequate legislation on the use of antimicrobials
- a veterinary profession which is well trained and supervised by law
- the allocation of the necessary resources to strengthen Veterinary Services so that they can exercise the appropriate controls
Ensuring the circulation of antibiotics under appropriate legislation
Antibiotics are not a harmless product which should be freely available for sale and use. Their sale should be legally supervised and the distribution of counterfeit products severely suppressed
Fostering excellence in the veterinary profession
The veterinary profession, in both its public and private sectors, has a crucial role to play in confronting antimicrobial resistance, particularly in overseeing the prescription and delivery of antimicrobial products.
For this reason, the OIE has also developed guidelines on the Veterinary Education Core Curriculum, covering the basic essentials of a well-organised profession which is reliant on well-trained and properly supervised professionals.
Moreover, the OIE advocates an appropriate legislative framework to ensure professional ethics and good governance of Veterinary Services within the veterinary profession. With this in mind, the Organisation is developing intergovernmental standards and programmes related to the functioning and constitution of national and regional Statutory Veterinary Bodies, which have the necessary legal powers to oversee degrees, ethics, professional excellence and the exclusion of those whose conduct is inappropriate.
In the face of antimicrobial resistance, veterinarians are part of the solution.
Capacity-building programmes for national Veterinary Services
International solidarity is crucial in helping developing and emerging countries to achieve the legislation, infrastructure and human and financial resources needed to implement and comply with the OIE standards.
As a result, the OIE provides continuing support to Veterinary Services; in particular, by means of the PVS Pathway (evaluation of Performance of Veterinary Services).
Furthermore, the OIE has created a network of National Focal Points, appointed by their governments, to develop or update legislation related to the production, importation, distribution and use of veterinary products, and, among other things, to establish the monitoring of antibiotic consumption. These National Focal Points provide technical support to their OIE National Delegates. To date, three series of seminars have been organised in the five regions of the OIE and the fourth series is under way.
We each have a role to play against antimicrobial resistance.
This page gives you access to various background materials on the problem of antimicrobial resistance. These elements are free-access, please don’t hesitate to use them and pass them on.
World Antimicrobial Awareness Week
The goal of this week is to raise awareness of the health risks posed by antimicrobial resistance and to promote good practice in this area of concern, to limit the emergence and spread of resistance throughout the world.
Infographic, Strategic Plan
Fact Sheet, Strategic Plan.pdf – 356 KB See the document
Report.pdf – 260 KB See the document
Fact Sheet.pdf – 179 KB See the document
Infographic.pdf – 874 KB See the document
Report.pdf – 334 KB See the document
Bulletin.pdf – 6 MB See the document
- Risks associated with the use of antimicrobials in animals worldwide (2015)
- Veterinary medicinal products and vaccines: indispensable tools for any effective animal health and welfare policy (2010)